Despite and Although are both used to contrast two things, but the difference is in the structure of the sentences.
Despite is a preposition. Followed by a noun or pronoun. Cannot link clauses.
- I love him despite his faults.
- Despite being much older than the others, he won the race.
- They went out despite the rain.
- Despite applying for hundred of jobs, she is still out of work.
- We helped them despite the difficulties.
- Despite the cool day, he don’t want to go out.
Although is a subordinating conjunction. Followed by a clause. Can link clauses.
- Although the weather is cold, everybody is out
- Although she speaks seldom, she says meaningful words.
- Although my car is very old, it still runs very well.
- I don’t want to sleep although I am tired.
- Although the weather was cold, we decided not to wear our jackets.
- Although Mark does whatever she asks, she isn’t pleased.